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Crystal structure of Thiocyanate hydrolase mutant R136W

Source organism: Thiobacillus thioparus
Biochemical function: thiocyanate hydrolase activity
Biological process: thiocyanate catabolic process
Cellular component: not assigned

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EC 3.5.5.8: Thiocyanate hydrolase

Reaction catalysed:
Thiocyanate + 2 H(2)O = carbonyl sulfide + NH(3) + HO(-)
Systematic name:
Thiocyanate aminohydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02979
Domain description: Nitrile hydratase, alpha chain
Occurring in:
  1. Thiocyanate hydrolase subunit gamma
The deposited structure of PDB entry 3vyg contains 4 copies of Pfam domain PF02979 (Nitrile hydratase, alpha chain) in Thiocyanate hydrolase subunit gamma. Showing 1 copy in chain C.

PF21006
Domain description: Nitrile hydratase beta subunit, N-terminal
Occurring in:
  1. Thiocyanate hydrolase subunit beta
The deposited structure of PDB entry 3vyg contains 4 copies of Pfam domain PF21006 (Nitrile hydratase beta subunit, N-terminal) in Thiocyanate hydrolase subunit beta. Showing 1 copy in chain B.

PF02211
Domain description: Nitrile hydratase beta subunit, C-terminal
Occurring in:
  1. Thiocyanate hydrolase subunit alpha
The deposited structure of PDB entry 3vyg contains 4 copies of Pfam domain PF02211 (Nitrile hydratase beta subunit, C-terminal) in Thiocyanate hydrolase subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036648
Domain description: Nitrile hydratase alpha /Thiocyanate hydrolase gamma superfamily
Occurring in:
  1. Thiocyanate hydrolase subunit gamma
IPR024690
Domain description: Nitrile hydratase beta subunit domain
Occurring in:
  1. Thiocyanate hydrolase subunit alpha
  2. Thiocyanate hydrolase subunit beta
IPR008990
Domain description: Electron transport accessory-like domain superfamily
Occurring in:
  1. Thiocyanate hydrolase subunit alpha
  2. Thiocyanate hydrolase subunit beta
IPR004232
Domain description: Nitrile hydratase alpha/Thiocyanate hydrolase gamma
Occurring in:
  1. Thiocyanate hydrolase subunit gamma
IPR023901
Domain description: Thiocyanate hydrolase, gamma subunit
Occurring in:
  1. Thiocyanate hydrolase subunit gamma
IPR023900
Domain description: Nitrile hydratase alpha subunit /Thiocyanate hydrolase gamma subunit
Occurring in:
  1. Thiocyanate hydrolase subunit gamma
IPR042262
Domain description: Nitrile hydratase beta subunit, N-terminal
Occurring in:
  1. Thiocyanate hydrolase subunit beta

Structure domains

CATH CATH domains
3.90.330.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nitrile Hydratase; Chain A
Homology: Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Occurring in:
  1. Thiocyanate hydrolase subunit gamma
The deposited structure of PDB entry 3vyg contains 4 copies of CATH domain 3.90.330.10 (Nitrile Hydratase; Chain A) in Thiocyanate hydrolase subunit gamma. Showing 1 copy in chain C.
1.10.472.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cyclin A; domain 1
Homology: Nitrile hydratase, beta subunit
Occurring in:
  1. Thiocyanate hydrolase subunit beta
The deposited structure of PDB entry 3vyg contains 4 copies of CATH domain 1.10.472.20 (Cyclin A; domain 1) in Thiocyanate hydrolase subunit beta. Showing 1 copy in chain B.
2.30.30.50
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 type barrels.
Occurring in:
  1. Thiocyanate hydrolase subunit alpha
The deposited structure of PDB entry 3vyg contains 4 copies of CATH domain 2.30.30.50 (SH3 type barrels.) in Thiocyanate hydrolase subunit alpha. Showing 1 copy in chain A.

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