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Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-121

Source organism: Trypanosoma cruzi strain CL Brener
Biochemical function: dihydroorotate dehydrogenase (fumarate) activity
Biological process: 'de novo' UMP biosynthetic process
Cellular component: cytoplasm

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EC 1.3.98.1: Dihydroorotate oxidase (fumarate)

Reaction catalysed:
(S)-dihydroorotate + fumarate = orotate + succinate
Systematic name:
(S)-dihydroorotate:fumarate oxidoreductase
Alternative Name(s):
  • DHOD
  • DHODase
  • DHOdehase
  • Dihydoorotic acid dehydrogenase
  • Dihydroorotate dehydrogenase
  • Dihydroorotate oxidase
  • Pyr4 (gene name)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01180
Domain description: Dihydroorotate dehydrogenase
Occurring in:
  1. Dihydroorotate dehydrogenase (fumarate)
The deposited structure of PDB entry 3w1x contains 2 copies of Pfam domain PF01180 (Dihydroorotate dehydrogenase) in Dihydroorotate dehydrogenase (fumarate). Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005720
Domain description: Dihydroorotate dehydrogenase, catalytic
Occurring in:
  1. Dihydroorotate dehydrogenase (fumarate)
IPR033886
Domain description: Dihydroorotate dehydrogenase, class 1A
Occurring in:
  1. Dihydroorotate dehydrogenase (fumarate)
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Dihydroorotate dehydrogenase (fumarate)
IPR012135
Domain description: Dihydroorotate dehydrogenase, class 1/ 2
Occurring in:
  1. Dihydroorotate dehydrogenase (fumarate)

Structure domains

CATH CATH domains
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Dihydroorotate dehydrogenase (fumarate)
The deposited structure of PDB entry 3w1x contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Dihydroorotate dehydrogenase (fumarate). Showing 1 copy in chain A.
2.30.26.10
Class: Mainly Beta
Architecture: Roll
Topology: Dihydroorotate Dehydrogenase A; chain A, domain 2
Homology: Dihydroorotate Dehydrogenase A, chain A, domain 2
Occurring in:
  1. Dihydroorotate dehydrogenase (fumarate)
The deposited structure of PDB entry 3w1x contains 2 copies of CATH domain 2.30.26.10 (Dihydroorotate Dehydrogenase A; chain A, domain 2) in Dihydroorotate dehydrogenase (fumarate). Showing 1 copy in chain A.

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