› 3wqn

X-ray diffraction
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
Tuberculosinyl diphosphate + adenosine = 1-tuberculosinyladenosine + diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tuberculosinyl adenosine transferase Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 34.13 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WJ61 (Residues: 1-296; Coverage: 100%)
Gene name: Rv3378c
Structure domains: Decaprenyl diphosphate synthase-like

Ligands and Environments

2 bound ligands:
Ligand PO4 2 x PO4
Ligand 9AX 1 x 9AX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P43212
Unit cell:
a: 106.454Å b: 106.454Å c: 66.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.24 0.261
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Resistance-resistant antibiotics.
Oldfield et al. (2014)
4 more

2 mentions without citation

Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.
Chan et al. (2014)
1 more