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Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA

Source organisms:
Biochemical function: DNA-binding transcription factor activity
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00178
Domain description: Ets-domain
Occurring in:
  1. Protein C-ets-1
The deposited structure of PDB entry 3wtv contains 2 copies of Pfam domain PF00178 (Ets-domain) in Protein C-ets-1. Showing 1 copy in chain C.

PF19525
Domain description: Ets1 N-terminal flanking region of Ets domain
Occurring in:
  1. Protein C-ets-1
The deposited structure of PDB entry 3wtv contains 2 copies of Pfam domain PF19525 (Ets1 N-terminal flanking region of Ets domain) in Protein C-ets-1. Showing 1 copy in chain C.

PF02312
Domain description: Core binding factor beta subunit
Occurring in:
  1. Core-binding factor subunit beta
The deposited structure of PDB entry 3wtv contains 2 copies of Pfam domain PF02312 (Core binding factor beta subunit) in Core-binding factor subunit beta. Showing 1 copy in chain B.

PF00853
Domain description: Runt domain
Occurring in:
  1. Runt-related transcription factor 1
The deposited structure of PDB entry 3wtv contains 2 copies of Pfam domain PF00853 (Runt domain) in Runt-related transcription factor 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000418
Domain description: Ets domain
Occurring in:
  1. Protein C-ets-1
IPR000040
Domain description: Acute myeloid leukemia 1 protein (AML1)/Runt
Occurring in:
  1. Runt-related transcription factor 1
IPR036552
Domain description: Core-binding factor, beta subunit superfamily
Occurring in:
  1. Core-binding factor subunit beta
IPR003417
Domain description: Core-binding factor, beta subunit
Occurring in:
  1. Core-binding factor subunit beta
IPR013524
Domain description: Runt domain
Occurring in:
  1. Runt-related transcription factor 1
IPR046328
Domain description: ETS family
Occurring in:
  1. Protein C-ets-1
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Protein C-ets-1
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Protein C-ets-1
IPR045688
Domain description: Ets1, N-terminal flanking region of Ets domain
Occurring in:
  1. Protein C-ets-1
IPR012346
Domain description: p53/RUNT-type transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Runt-related transcription factor 1
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Runt-related transcription factor 1

Structure domains

CATH CATH domains
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Protein C-ets-1
The deposited structure of PDB entry 3wtv contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Protein C-ets-1. Showing 1 copy in chain C.
2.40.250.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Polyomavirus Enhancer Binding Protein 2; Chain: A;
Homology: Core binding factor, beta subunit
Occurring in:
  1. Core-binding factor subunit beta
The deposited structure of PDB entry 3wtv contains 2 copies of CATH domain 2.40.250.10 (Polyomavirus Enhancer Binding Protein 2; Chain: A;) in Core-binding factor subunit beta. Showing 1 copy in chain B.
2.60.40.720
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Runt-related transcription factor 1
The deposited structure of PDB entry 3wtv contains 2 copies of CATH domain 2.60.40.720 (Immunoglobulin-like) in Runt-related transcription factor 1. Showing 1 copy in chain A.

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