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Crystal structure of the human vitamin D receptor ligand binding domain complexed with 1-((((1S,2R,6R,Z)-2,6-dihydroxy-4-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-3-methylenecyclohexyl)oxy)methyl)cyclopropanecarbonitrile

Source organism: Homo sapiens
Biochemical function: nuclear receptor activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Vitamin D3 receptor
The deposited structure of PDB entry 3wwr contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Vitamin D3 receptor. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Vitamin D3 receptor
IPR001728
Domain description: Thyroid hormone receptor
Occurring in:
  1. Vitamin D3 receptor
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Vitamin D3 receptor
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Vitamin D3 receptor

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Vitamin D3 receptor
The deposited structure of PDB entry 3wwr contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Vitamin D3 receptor. Showing 1 copy in chain A.

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