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S221M V223F Y359A mutant of 4-Hydroxymandelate synthase from Streptomyces coelicolor

Source organism: Streptomyces coelicolor A3(2)
Biochemical function: dioxygenase activity
Biological process: aromatic amino acid metabolic process
Cellular component: not assigned

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EC 1.13.11.46: 4-hydroxymandelate synthase

Reaction catalysed:
4-hydroxyphenylpyruvate + O(2) = (S)-4-hydroxymandelate + CO(2)
Systematic name:
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
Alternative Name(s):
  • 4-hydroxyphenylpyruvate dioxygenase II

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00903
Domain description: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 3zgj contains 4 copies of Pfam domain PF00903 (Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) in VOC domain-containing protein. Showing 2 copies in chain B.

InterPro InterPro annotations
IPR005956
Domain description: 4-hydroxyphenylpyruvate dioxygenase
Occurring in:
  1. VOC domain-containing protein
IPR029068
Domain description: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. VOC domain-containing protein
IPR037523
Domain description: Vicinal oxygen chelate (VOC) domain
Occurring in:
  1. VOC domain-containing protein
IPR041735
Domain description: 4-hydroxyphenylpyruvate dioxygenase, C-terminal
Occurring in:
  1. VOC domain-containing protein
IPR004360
Domain description: Glyoxalase/fosfomycin resistance/dioxygenase domain
Occurring in:
  1. VOC domain-containing protein
IPR041736
Domain description: 4-hydroxyphenylpyruvate dioxygenase, N-terminal
Occurring in:
  1. VOC domain-containing protein

Structure domain

CATH CATH domain
3.10.180.10
Class: Alpha Beta
Architecture: Roll
Topology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
Homology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 3zgj contains 4 copies of CATH domain 3.10.180.10 (2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1) in VOC domain-containing protein. Showing 2 copies in chain B.

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