3zr5

X-ray diffraction
2.1Å resolution

STRUCTURE OF GALACTOCEREBROSIDASE FROM MOUSE

Released:
Source organism: Mus musculus
Primary publication:
Insights into Krabbe disease from structures of galactocerebrosidase.
Proc Natl Acad Sci U S A 108 15169-73 (2011)
PMID: 21876145

Function and Biology Details

Reaction catalysed:
D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galactocerebrosidase Chain: A
Molecule details ›
Chain: A
Length: 656 amino acids
Theoretical weight: 74.75 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P54818 (Residues: 40-684; Coverage: 100%)
Gene name: Galc
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: R32
Unit cell:
a: 249.904Å b: 249.904Å c: 77.826Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.181 0.214
Expression system: Homo sapiens