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The 3-dimensional structure of MpgP from Thermus thermophilus HB27, in complex with the alpha-mannosylglycerate and orthophosphate reaction products.

Source organism: Thermus thermophilus HB27
Biochemical function: mannosyl-3-phosphoglycerate phosphatase activity
Biological process: mannosylglycerate biosynthetic process
Cellular component: cytosol

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EC 3.1.3.70: Mannosyl-3-phosphoglycerate phosphatase

Reaction catalysed:
2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate
Systematic name:
Alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF08282
Domain description: haloacid dehalogenase-like hydrolase
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase
The deposited structure of PDB entry 3zu6 contains 2 copies of Pfam domain PF08282 (haloacid dehalogenase-like hydrolase) in Mannosyl-3-phosphoglycerate phosphatase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR006381
Domain description: HAD-superfamily hydrolase, superfamily IIB, MPGP
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase
IPR033980
Domain description: Mannosyl-3-phosphoglycerate phosphatase, thermophiles
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase
IPR006379
Domain description: HAD-superfamily hydrolase, subfamily IIB
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase

Structure domains

CATH CATH domains
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase
The deposited structure of PDB entry 3zu6 contains 2 copies of CATH domain 3.40.50.1000 (Rossmann fold) in Mannosyl-3-phosphoglycerate phosphatase. Showing 1 copy in chain B.
3.30.980.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Threonyl-tRNA Synthetase; Chain A, domain 2
Homology: Putative mannosyl-3-phosphoglycerate phosphatase; domain 2
Occurring in:
  1. Mannosyl-3-phosphoglycerate phosphatase
The deposited structure of PDB entry 3zu6 contains 2 copies of CATH domain 3.30.980.20 (Threonyl-tRNA Synthetase; Chain A, domain 2) in Mannosyl-3-phosphoglycerate phosphatase. Showing 1 copy in chain B.

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