› 3zy1

X-ray diffraction
2.15Å resolution

Crystal structure of the human p63 tetramerization domain

Released:
DOI: 10.2210/pdb3zy1/pdb
PDB entry 3zy1 coloured by chain, front view.
PDB entry 3zy1 coloured by chain, side view.
PDB entry 3zy1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and kinetic stability of the p63 tetramerization domain.
Natan E, Joerger AC
OpenAccess logo J Mol Biol 415 503-13 (2012)
PMID: 22100306

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190572 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein 63 Chain: A
Molecule details ›
Chain: A
Length: 46 amino acids
Theoretical weight: 5.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H3D4 (Residues: 398-441; Coverage: 7%)
Gene names: KET, P63, P73H, P73L, TP63, TP73L
Sequence domains: P53 tetramerisation motif
Structure domains: p53-like tetramerisation domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P422
Unit cell:
a: 58.198Å b: 58.198Å c: 39.328Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.285
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.
Joerger et al. (2016)
6 more

2 mentions without citation

Structure and kinetic stability of the p63 tetramerization domain.
Natan et al. (2012)
1 more