› 4b4o

X-ray diffraction
2.7Å resolution

Crystal Structure of human epimerase family protein SDR39U1 (isoform2) with NADPH

Released:
DOI: 10.2210/pdb4b4o/pdb
PDB entry 4b4o coloured by chain, front view.
PDB entry 4b4o coloured by chain, side view.
PDB entry 4b4o coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Vollmar M, Muniz JRC, Shafqat N, Picaud S, Krojer T, Chaikuad A, Pike ACW, Yue WW, Filippakopoulos P, Kavanagh KL, von Delft F, Weigelt J, Arrowsmith CH, Bountra C, Edwards A, Oppermann U

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576283 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epimerase family protein SDR39U1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 298 amino acids
Theoretical weight: 32.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NRG7 (Residues: 1-291; Coverage: 99%)
Gene names: C14orf124, HCDI, SDR39U1
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

2 bound ligands:
Ligand NDP 8 x NDP
Ligand PE4 8 x PE4
1 modified residue:
Ligand MSE 32 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 80.824Å b: 83.362Å c: 105.191Å
α: 89.93° β: 76.73° γ: 71.52°
R-values:
R R work R free
0.2 0.198 0.231
Expression system: Escherichia coli BL21(DE3)

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