› 4bh0

X-ray diffraction
2.36Å resolution

H5 (tyTy) Influenza Virus Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN

Released:
DOI: 10.2210/pdb4bh0/pdb
PDB entry 4bh0 coloured by chain, front view.
PDB entry 4bh0 coloured by chain, side view.
PDB entry 4bh0 coloured by chain, top view.
Source organism: Influenza A virus (A/turkey/Turkey/1/2005(H5N1))
Primary publication:
Receptor binding by a ferret-transmissible H5 avian influenza virus.
Xiong X, Coombs PJ, Martin SR, Liu J, Xiao H, McCauley JW, Locher K, Walker PA, Collins PJ, Kawaoka Y, Skehel JJ, Gamblin SJ
Nature 497 392-6 (2013)
PMID: 23615615

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173117 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 327 amino acids
Theoretical weight: 36.98 KDa
Source organism: Influenza A virus (A/turkey/Turkey/1/2005(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q207Z6 (Residues: 17-338; Coverage: 57%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 166 amino acids
Theoretical weight: 19.13 KDa
Source organism: Influenza A virus (A/turkey/Turkey/1/2005(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q207Z6 (Residues: 347-512; Coverage: 29%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, SIA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: GAL, SIA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 3 x NAG
Ligand PO4 5 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 70.346Å b: 228.296Å c: 71.267Å
α: 90° β: 114.01° γ: 90°
R-values:
R R work R free
0.214 0.211 0.258
Expression system: Spodoptera frugiperda

Quick links

Citations

43 review citations

Role of receptor binding specificity in influenza A virus transmission and pathogenesis.
de Graaf et al. (2014)
42 more

3 mentions without citation

New insights into influenza A specificity: an evolution of paradigms.
Ji et al. (2017)
2 more