4bst

X-ray diffraction
4.3Å resolution

Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P6122 crystal form

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-522037 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Leucine-rich repeat-containing G-protein coupled receptor 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 539 amino acids
Theoretical weight: 60.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75473 (Residues: 22-543; Coverage: 59%)
Gene names: GPR49, GPR67, LGR5
Sequence domains:
R-spondin-1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 126 amino acids
Theoretical weight: 13.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2MKA7 (Residues: 31-146; Coverage: 48%)
Gene name: RSPO1
Sequence domains: Furin-like repeat, cysteine-rich

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P6122
Unit cell:
a: 131.1Å b: 131.1Å c: 531.97Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.243 0.268
Expression system: Homo sapiens