› 4cbz

X-ray diffraction
2.5Å resolution

Notch ligand, Jagged-1, contains an N-terminal C2 domain

Released:
DOI: 10.2210/pdb4cbz/pdb
PDB entry 4cbz coloured by chain, front view.
PDB entry 4cbz coloured by chain, side view.
PDB entry 4cbz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis uncovers lipid-binding properties of Notch ligands.
Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM
OpenAccess logo Cell Rep 5 861-7 (2013)
PMID: 24239355

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160269 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein jagged-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P78504 (Residues: 32-335; Coverage: 26%)
Gene names: JAG1, JAGL1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 56.93Å b: 59.84Å c: 62.94Å
α: 95.04° β: 101.9° γ: 98.7°
R-values:
R R work R free
0.206 0.204 0.246
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Notch signalling in context.
Bray SJ. (2016)
8 more

1 mention without citation

Functional characterization of 2,832 JAG1 variants supports reclassification for Alagille syndrome and improves guidance for clinical variant interpretation.
Gilbert et al. (2024)