› 4cim

X-ray diffraction
1.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187783 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 163 amino acids
Theoretical weight: 17.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92843 (Residues: 1-163; Coverage: 85%)
Gene names: BCL2L2, BCLW, KIAA0271
Sequence domains:
Bcl-2-like protein 2 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 21 amino acids
Theoretical weight: 2.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92843 (Residues: 38-58; Coverage: 11%)
Gene names: BCL2L2, BCLW, KIAA0271

Ligands and Environments

1 bound ligand:
Ligand EDO 16 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 41.922Å b: 60.726Å c: 67.098Å
α: 90° β: 105.85° γ: 90°
R-values:
R R work R free
0.187 0.186 0.21
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Mitochondria and apoptosis: emerging concepts.
Li et al. (2015)
5 more

5 mentions without citation

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.
Luna-Vargas et al. (2016)
4 more