› 4e93

X-ray diffraction
1.84Å resolution

Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684

Released:
DOI: 10.2210/pdb4e93/pdb
PDB entry 4e93 coloured by chain, front view.
PDB entry 4e93 coloured by chain, side view.
PDB entry 4e93 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.
Hellwig S, Miduturu CV, Kanda S, Zhang J, Filippakopoulos P, Salah E, Deng X, Choi HG, Zhou W, Hur W, Knapp S, Gray NS, Smithgall TE
Chem Biol 19 529-40 (2012)
PMID: 22520759

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-530066 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fes/Fps Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 42.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07332 (Residues: 448-822; Coverage: 46%)
Gene names: FES, FPS
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GUI 1 x GUI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 54.97Å b: 35.33Å c: 100.72Å
α: 90° β: 96.58° γ: 90°
R-values:
R R work R free
0.188 0.186 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.
Siveen et al. (2018)
2 more

1 mention without citation

Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis.
van der Wel et al. (2020)