› 4fie

X-ray diffraction
3.11Å resolution

Full-length human PAK4

Released:
DOI: 10.2210/pdb4fie/pdb
PDB entry 4fie coloured by chain, front view.
PDB entry 4fie coloured by chain, side view.
PDB entry 4fie coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ
Proc Natl Acad Sci U S A 109 16107-12 (2012)
PMID: 22988085

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 423 amino acids
Theoretical weight: 47.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 5-591; Coverage: 71%)
  • Best match: O96013-2 (Residues: 5-426)
Gene names: KIAA1142, PAK4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ANP 2 x ANP
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P3
Unit cell:
a: 141.537Å b: 141.537Å c: 61.893Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.257 0.256 0.276
Expression system: Escherichia coli

Quick links

Citations

20 review citations

PAK signalling during the development and progression of cancer.
Radu et al. (2014)
19 more

7 mentions without citation

Recent advances on development of p21-activated kinase 4 inhibitors as anti-tumor agents.
Li et al. (2022)
6 more