› 4fu6

X-ray diffraction
2.1Å resolution

Crystal structure of the PSIP1 PWWP domain

Released:
DOI: 10.2210/pdb4fu6/pdb
PDB entry 4fu6 coloured by chain, front view.
PDB entry 4fu6 coloured by chain, side view.
PDB entry 4fu6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and function of the nucleosome-binding PWWP domain.
Qin S, Min J
Trends Biochem Sci 39 536-47 (2014)
PMID: 25277115

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75475 (Residues: 1-135; Coverage: 26%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand GOL 1 x GOL
Ligand UNX 5 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P43212
Unit cell:
a: 45.96Å b: 45.96Å c: 156.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

29 review citations

Reading m6A in the Transcriptome: m6A-Binding Proteins.
Patil et al. (2018)
28 more

5 mentions without citation

Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains.
Weaver et al. (2018)
4 more