› 4h5v

X-ray diffraction
1.75Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145675 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock cognate 71 kDa protein Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 42.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P11142 (Residues: 2-384; Coverage: 59%)
Gene names: HSC70, HSP73, HSPA10, HSPA8
Sequence domains: Hsp70 protein
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand SO4 3 x SO4
Ligand MG 1 x MG
Ligand CL 1 x CL
Ligand GOL 4 x GOL
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: P21212
Unit cell:
a: 76.741Å b: 102.175Å c: 54.524Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.215
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates.
Bonam et al. (2019)
7 other articles