› 4hjt

X-ray diffraction
1.45Å resolution

Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide

Released:
DOI: 10.2210/pdb4hjt/pdb
PDB entry 4hjt coloured by chain, front view.
PDB entry 4hjt coloured by chain, side view.
PDB entry 4hjt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW
J Am Chem Soc 135 17869-80 (2013)
PMID: 24180271

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 18A 2 x 18A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21212
Unit cell:
a: 42.966Å b: 85.157Å c: 64.132Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.165 0.187
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Lysine-Targeted Inhibitors and Chemoproteomic Probes.
Cuesta et al. (2019)
13 other articles

1 mention without citation

Predicting binding sites from unbound versus bound protein structures.
Clark et al. (2020)