› 4jry

X-ray diffraction
2.8Å resolution

Crystal Structure of SB47 TCR-HLA B*3505-LPEP complex

Released:
DOI: 10.2210/pdb4jry/pdb
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PDB entry 4jry coloured by chain, front view.
PDB entry 4jry coloured by chain, side view.
PDB entry 4jry coloured by chain, top view.
Source organisms:
Primary publication:
Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule.
Liu YC, Miles JJ, Neller MA, Gostick E, Price DA, Purcell AW, McCluskey J, Burrows SR, Rossjohn J, Gras S
OpenAccess logo J Biol Chem 288 15442-54 (2013)
PMID: 23569211

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-111516 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: C5MK56 (Residues: 25-300; Coverage: 82%)
Gene name: HLA-B
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Lytic switch protein BZLF1 Chain: C
T cell receptor alpha chain constant Chain: D
T cell receptor beta constant 1 Chain: E

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: I4
Unit cell:
a: 237.6Å b: 237.6Å c: 61.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.233
Expression systems:
  • Escherichia coli
  • Not provided

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Citations

5 review citations

T cell antigen receptor recognition of antigen-presenting molecules.
Rossjohn et al. (2015)
4 more

13 mentions without citation

TCR Recognition of Peptide-MHC-I: Rule Makers and Breakers.
Szeto et al. (2020)
12 more

PDB-REDO

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