› 4kv5

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-219742 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transforming growth factor beta-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 112 amino acids
Theoretical weight: 12.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01137 (Residues: 279-390; Coverage: 31%)
Gene names: TGFB, TGFB1
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Single-chain variable fragment GC1009 Chains: E, G, H, J
Molecule details ›
Chains: E, G, H, J
Length: 252 amino acids
Theoretical weight: 26.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 108.188Å b: 171.769Å c: 109.876Å
α: 90° β: 111.3° γ: 90°
R-values:
R R work R free
0.233 0.229 0.3
Expression system: Escherichia coli

Quick links

Citations

4 review citations

TGFβ-Directed Therapeutics: 2020.
Teicher BA. (2021)
3 more

13 mentions without citation

Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions.
Moulin et al. (2014)
12 more

PDB-REDO

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