› 4l55

X-ray diffraction
1.65Å resolution

X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu

Released:
DOI: 10.2210/pdb4l55/pdb
PDB entry 4l55 coloured by chain, front view.
PDB entry 4l55 coloured by chain, side view.
PDB entry 4l55 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Investigating the ruthenium metalation of proteins: X-ray structure and Raman microspectroscopy of the complex between RNase A and AziRu.
Vergara A, Russo Krauss I, Montesarchio D, Paduano L, Merlino A
Inorg Chem 52 10714-6 (2013)
PMID: 24093479

Function and Biology Details

Reaction catalysed: 
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
Ligand RU 2 x RU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 100.104Å b: 32.532Å c: 72.484Å
α: 90° β: 90.41° γ: 90°
R-values:
R R work R free
0.203 0.203 0.244

Quick links

Citations

1 review citation

Anticancer Ruthenium(III) Complexes and Ru(III)-Containing Nanoformulations: An Update on the Mechanism of Action and Biological Activity.
Riccardi et al. (2019)
18 other articles

1 mention without citation

Exploring the coordination chemistry of ruthenium complexes with lysozymes: structural and in-solution studies.
Oszajca et al. (2024)