› 4l6r

X-ray diffraction
3.3Å resolution

Structure of the class B human glucagon G protein coupled receptor

Released:
DOI: 10.2210/pdb4l6r/pdb
PDB entry 4l6r coloured by chain, front view.
PDB entry 4l6r coloured by chain, side view.
PDB entry 4l6r coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the human glucagon class B G-protein-coupled receptor.
Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, Zhou C, Xu Q, Wacker D, Joseph JS, Liu W, Lau J, Cherezov V, Katritch V, Wang MW, Stevens RC
Nature 499 444-9 (2013)
PMID: 23863937

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142099 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucagon receptor; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 425 amino acids
Theoretical weight: 48.15 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P47871 (Residues: 123-434; Coverage: 69%)
Gene names: GCGR, cybC
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 56.615Å b: 66.651Å c: 163.331Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.286 0.284 0.338
Expression system: Spodoptera frugiperda

Quick links

Citations

52 review citations

Mechanisms of signalling and biased agonism in G protein-coupled receptors.
Wootten et al. (2018)
51 more

70 mentions without citation

Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Isberg et al. (2015)
69 more