4nxr

X-ray diffraction
1.9Å resolution

Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide

Released:

Function and Biology Details

Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-547961 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Rho guanine nucleotide exchange factor TIAM1 Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13009 (Residues: 841-930; Coverage: 6%)
Gene name: TIAM1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Neurexin-2-beta Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P58401 (Residues: 659-666; Coverage: 1%)
Gene name: NRXN2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 26.358Å b: 50.323Å c: 61.942Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.149 0.147 0.195
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided