› 4p6a

X-ray diffraction
1.4Å resolution

Crystal structure of a potent anti-HIV lectin actinohivin in complex with alpha-1,2-mannotriose

Released:
DOI: 10.2210/pdb4p6a/pdb
PDB entry 4p6a coloured by chain, front view.
PDB entry 4p6a coloured by chain, side view.
PDB entry 4p6a coloured by chain, top view.
Source organism: actinomycete K97-0003
Primary publication:
The characteristic structure of anti-HIV actinohivin in complex with three HMTG D1 chains of HIV-gp120.
Zhang F, Hoque MM, Jiang J, Suzuki K, Tsunoda M, Takeda Y, Ito Y, Kawai G, Tanaka H, Takénaka A
Chembiochem 15 2766-73 (2014)
PMID: 25403811

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192153 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Actinohivin Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.53 KDa
Source organism: actinomycete K97-0003
UniProt:
  • Canonical: Q9KWN0 (Residues: 47-160; Coverage: 85%)
Gene name: ath
Sequence domains: Ricin-type beta-trefoil lectin domain
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: C2
Unit cell:
a: 98.97Å b: 27.23Å c: 56.91Å
α: 90° β: 119.79° γ: 90°
R-values:
R R work R free
0.144 0.141 0.169

Quick links

Citations

2 review citations

Antiviral lectins: Selective inhibitors of viral entry.
Mitchell et al. (2017)
1 more

3 mentions without citation

Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.
Barre et al. (2019)
2 more