› 4pbv

X-ray diffraction
2.5Å resolution

Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC

Released:
DOI: 10.2210/pdb4pbv/pdb
PDB entry 4pbv coloured by chain, front view.
PDB entry 4pbv coloured by chain, side view.
PDB entry 4pbv coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.
Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR
OpenAccess logo Nat Commun 5 5209 (2014)
PMID: 25385546

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-123329 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NT-3 growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 30.4 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q91044 (Residues: 32-302; Coverage: 32%)
  • Best match: Q91044-4 (Residues: 1-204)
Gene names: NTRK3, TRKC
Sequence domains:
Receptor-type tyrosine-protein phosphatase S Chains: C, D, E
Molecule details ›
Chains: C, D, E
Length: 299 amino acids
Theoretical weight: 32.72 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: F1NWE3 (Residues: 29-320; Coverage: 19%)
  • Best match: F1NWE3-2 (Residues: 29-316)
Gene name: PTPRS
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 5 x NAG
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 68.3Å b: 122.16Å c: 98.61Å
α: 90° β: 109.79° γ: 90°
R-values:
R R work R free
0.211 0.209 0.247
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Spatial and temporal arrangement of neuronal intrinsic and extrinsic mechanisms controlling axon regeneration.
Tedeschi et al. (2017)
14 more

3 mentions without citation

Roles of glycosaminoglycans as regulators of ligand/receptor complexes.
Smock et al. (2018)
2 more