› 4q30

X-ray diffraction
2.03Å resolution

Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5

Released:
DOI: 10.2210/pdb4q30/pdb
PDB entry 4q30 coloured by chain, front view.
PDB entry 4q30 coloured by chain, side view.
PDB entry 4q30 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development.
Martinez M, Ahmed AH, Loh AP, Oswald RE
OpenAccess logo Biochemistry 53 3790-5 (2014)
PMID: 24850223

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 258 amino acids
Theoretical weight: 28.81 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 414-527, 653-794; Coverage: 30%)
  • Best match: P19491-2 (Residues: 414-527, 653-794)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand NWD 3 x NWD
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Unit cell:
a: 47.797Å b: 113.27Å c: 164.321Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.23
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Willardiine and Its Synthetic Analogues: Biological Aspects and Implications in Peptide Chemistry of This Nucleobase Amino Acid.
Palumbo et al. (2022)
3 other articles

1 mention without citation

Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development.
Martinez et al. (2014)