4r67

X-ray diffraction
2.89Å resolution

Human constitutive 20S proteasome in complex with carfilzomib

Released:
Model geometry
Fit model/data
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127173 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Proteasome subunit alpha type-6 Chains: A, O, c, q
Molecule details ›
Chains: A, O, c, q
Length: 244 amino acids
Theoretical weight: 27.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60900 (Residues: 2-245; Coverage: 99%)
Gene names: PROS27, PSMA6
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type-2 Chains: B, P, d, r
Molecule details ›
Chains: B, P, d, r
Length: 233 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25787 (Residues: 2-234; Coverage: 100%)
Gene names: HC3, PSC3, PSMA2
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type-4 Chains: C, Q, e, s
Proteasome subunit alpha type-7 Chains: D, R, f, t
Proteasome subunit alpha type-5 Chains: E, S, g, u
Proteasome subunit alpha type-1 Chains: F, T, h, v
Proteasome subunit alpha type-3 Chains: G, U, i, w
Proteasome subunit beta type-6 Chains: H, V, j, x
Proteasome subunit beta type-7 Chains: I, W, k, y
Proteasome subunit beta type-3 Chains: J, X, l, z
Proteasome subunit beta type-2 Chains: 0, K, Y, m
Proteasome subunit beta type-5 Chains: 3, L, Z, n
Proteasome subunit beta type-1 Chains: 1, M, a, o
Proteasome subunit beta type-4 Chains: 2, N, b, p

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 171.989Å b: 201.027Å c: 225.585Å
α: 90° β: 107.93° γ: 90°
R-values:
R R work R free
0.217 0.215 0.245