› 4rfn

X-ray diffraction
3.21Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211669 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein gp160 Chains: A, G
Molecule details ›
Chains: A, G
Length: 353 amino acids
Theoretical weight: 39.16 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED31 (Residues: 43-486; Coverage: 41%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
FAB HEAVY CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4 Chains: B, H
Molecule details ›
Chains: B, H
Length: 233 amino acids
Theoretical weight: 24.85 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
Structure domains: Immunoglobulins
FAB LIGHT CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4 Chains: C, L
Molecule details ›
Chains: C, L
Length: 216 amino acids
Theoretical weight: 22.72 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
Structure domains: Immunoglobulins
T-CELL SURFACE GLYCOPROTEIN CD4 mimetic M48 Chains: D, M
Molecule details ›
Chains: D, M
Length: 28 amino acids
Theoretical weight: 2.94 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NAG 18 x NAG
1 modified residue:
Ligand DPR 2 x DPR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P2
Unit cell:
a: 110.255Å b: 77.827Å c: 127.587Å
α: 90° β: 114.26° γ: 90°
R-values:
R R work R free
0.276 0.273 0.332
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

3 review citations

Survivors Remorse: antibody-mediated protection against HIV-1.
Lewis et al. (2017)
2 more

2 mentions without citation

Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity.
Tolbert et al. (2019)
1 more