› 4rzf

X-ray diffraction
1.99Å resolution

Crystal Structure Analysis of the NUR77 Ligand Binding Domain, S441W mutant

Released:
DOI: 10.2210/pdb4rzf/pdb
PDB entry 4rzf coloured by chain, front view.
PDB entry 4rzf coloured by chain, side view.
PDB entry 4rzf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q
Nat Chem Biol 11 339-46 (2015)
PMID: 25822914

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-540298 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 4immunitygroup A member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 28.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22736 (Residues: 351-598; Coverage: 42%)
Gene names: GFRP1, HMR, NAK1, NR4A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 74.542Å b: 76.183Å c: 128.095Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.227
Expression system: Escherichia coli BL21(DE3)

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Citations

18 review citations

Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition.
Menon et al. (2016)
17 more

2 mentions without citation

Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB.
Garton et al. (2018)
1 more