› 4tvq

X-ray diffraction
2.8Å resolution

CCM3 in complex with CCM2 LD-like motif

Released:
DOI: 10.2210/pdb4tvq/pdb
PDB entry 4tvq coloured by chain, front view.
PDB entry 4tvq coloured by chain, side view.
PDB entry 4tvq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.
Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA
OpenAccess logo J Cell Biol 208 987-1001 (2015)
PMID: 25825518

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189710 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Programmed cell death protein 10 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 214 amino acids
Theoretical weight: 24.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9BUL8 (Residues: 1-212; Coverage: 100%)
Gene names: CCM3, PDCD10, TFAR15
Sequence domains:
Structure domains:
Cerebral cavernous malformations 2 protein Chain: E
Molecule details ›
Chain: E
Length: 16 amino acids
Theoretical weight: 1.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9BSQ5 (Residues: 224-239; Coverage: 4%)
Gene names: C7orf22, CCM2, PP10187

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 61.855Å b: 113.552Å c: 120.034Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.239 0.277
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

10 review citations

Cerebral Cavernous Malformations: Review of the Genetic and Protein-Protein Interactions Resulting in Disease Pathogenesis.
Baranoski et al. (2016)
9 more

1 mention without citation

CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.
Draheim et al. (2015)