› 4w5s

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131875 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase tankyrase-1 Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 24.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95271 (Residues: 1105-1314; Coverage: 16%)
Gene names: PARP5A, PARPL, TIN1, TINF1, TNKS, TNKS1
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain
Structure domains: Phosphoenolpyruvate Carboxykinase; domain 3

Ligands and Environments

3 bound ligands:
Ligand GOL 1 x GOL
Ligand 3J1 1 x 3J1
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: I212121
Unit cell:
a: 81.01Å b: 81.93Å c: 82.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.263
Expression system: Escherichia coli

Quick links

Citations

7 review citations

WNT Signaling in Cardiac and Vascular Disease.
Foulquier et al. (2018)
6 more

2 mentions without citation

Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
Johannes et al. (2015)
1 more