› 4wn3

X-ray diffraction
1.8Å resolution

Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(NH)P

Released:
DOI: 10.2210/pdb4wn3/pdb
PDB entry 4wn3 coloured by chain, front view.
PDB entry 4wn3 coloured by chain, side view.
PDB entry 4wn3 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Entry authors: Bang MB, Molich U, Hansen MR, Grubmeyer C, Harris P

Function and Biology Details

Reaction catalysed: 
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146536 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orotate phosphoribosyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 25.48 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P13298 (Residues: 1-226; Coverage: 100%)
Gene names: PYR5, URA5, YM8339.13, YML106W
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand 3R3 1 x 3R3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P43212
Unit cell:
a: 62.01Å b: 62.01Å c: 132.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.238
Expression system: Escherichia coli

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