› 4x07

X-ray diffraction
1.46Å resolution

Crystal structure of P domain from norovirus strain Saga4 in complex with HBGA type A (triglycan)

Released:
DOI: 10.2210/pdb4x07/pdb
PDB entry 4x07 coloured by chain, front view.
PDB entry 4x07 coloured by chain, side view.
PDB entry 4x07 coloured by chain, top view.
Source organism: Norovirus Hu/GII-4/Saga4/2006/JP
Primary publication:
Human noroviruses' fondness for histo-blood group antigens.
Singh BK, Leuthold MM, Hansman GS
J Virol 89 2024-40 (2015)
PMID: 25428879

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
VP1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 307 amino acids
Theoretical weight: 33.88 KDa
Source organism: Norovirus Hu/GII-4/Saga4/2006/JP
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B5BTR7 (Residues: 225-530; Coverage: 57%)
Sequence domains: Calicivirus coat protein C-terminal
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLA, FUC, A2G
Carbohydrate polymer
1 bound ligand:
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 97.96Å b: 58.64Å c: 114.59Å
α: 90° β: 105.49° γ: 90°
R-values:
R R work R free
0.167 0.165 0.193
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Human Milk Oligosaccharides as Promising Antivirals.
Morozov et al. (2018)
14 more

5 mentions without citation

Human noroviruses' fondness for histo-blood group antigens.
Singh et al. (2015)
4 more