› 4xfx

X-ray diffraction
2.43Å resolution

Structure of the native full-length HIV-1 capsid protein

Released:
DOI: 10.2210/pdb4xfx/pdb
PDB entry 4xfx coloured by chain, front view.
PDB entry 4xfx coloured by chain, side view.
PDB entry 4xfx coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Primary publication:
STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Gres AT, Kirby KA, KewalRamani VN, Tanner JJ, Pornillos O, Sarafianos SG
Science 349 99-103 (2015)
PMID: 26044298

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.63 KDa
Source organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand IOD 7 x IOD
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P6
Unit cell:
a: 92.328Å b: 92.328Å c: 57.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.222 0.249
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

32 review citations

HIV-1 assembly, release and maturation.
Freed EO. (2015)
31 more

54 mentions without citation

Inhibitors of the HIV-1 capsid, a target of opportunity.
Carnes et al. (2018)
53 more