› 4xyn

X-ray diffraction
2.55Å resolution

X-ray structure of Ca(2+)-S100B with human RAGE-derived W61 peptide

Released:
DOI: 10.2210/pdb4xyn/pdb
PDB entry 4xyn coloured by chain, front view.
PDB entry 4xyn coloured by chain, side view.
PDB entry 4xyn coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex.
Jensen JL, Indurthi VS, Neau DB, Vetter SW, Colbert CL
Acta Crystallogr D Biol Crystallogr 71 1176-83 (2015)
PMID: 25945582

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-137554 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Advanced glycosylation end product-specific receptor Chain: P
Molecule details ›
Chain: P
Length: 15 amino acids
Theoretical weight: 1.65 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q15109 (Residues: 54-68; Coverage: 4%)
Gene names: AGER, RAGE
Protein S100-B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 92 amino acids
Theoretical weight: 10.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04271 (Residues: 1-92; Coverage: 100%)
Gene name: S100B
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 68.785Å b: 86.684Å c: 66.534Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.254
Expression systems:
  • Not provided
  • Escherichia coli

Quick links

Citations

1 review citation

An oscillopathic approach to developmental dyslexia: From genes to speech processing.
Jiménez-Bravo et al. (2017)
5 other articles

3 mentions without citation

Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex.
Jensen et al. (2015)
2 more