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CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 5-(2-AMINO- PYRIMIDIN-4-YL)-1H-PYRROLE INHIBITOR

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.11.21: Polo kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (spindle-pole-dependent)
Alternative Name(s):
  • Cdc5
  • Cdc5p
  • PLK
  • POLO kinase
  • Plk
  • Plk1
  • Plo1
  • Polo serine-threonine kinase
  • Polo-like kinase
  • Polo-like kinase 1
  • STK21
  • Serine/threonine-specific Drosophila kinase polo

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1
The deposited structure of PDB entry 4a4l contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Serine/threonine-protein kinase PLK1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Serine/threonine-protein kinase PLK1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Serine/threonine-protein kinase PLK1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase PLK1
IPR033702
Domain description: Polo-like kinase 1, catalytic domain
Occurring in:
  1. Serine/threonine-protein kinase PLK1

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Serine/threonine-protein kinase PLK1
The deposited structure of PDB entry 4a4l contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Serine/threonine-protein kinase PLK1. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Serine/threonine-protein kinase PLK1
The deposited structure of PDB entry 4a4l contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Serine/threonine-protein kinase PLK1. Showing 1 copy in chain A.

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