› 4adt

X-ray diffraction
2.42Å resolution

Crystal structure of plasmodial PLP synthase

Released:
DOI: 10.2210/pdb4adt/pdb
PDB entry 4adt coloured by chain, front view.
PDB entry 4adt coloured by chain, side view.
PDB entry 4adt coloured by chain, top view.
Source organism: Plasmodium berghei
Primary publication:
Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme.
Guédez G, Hipp K, Windeisen V, Derrer B, Gengenbacher M, Böttcher B, Sinning I, Kappes B, Tews I
Structure 20 172-84 (2012)
PMID: 22244765

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PYRIDOXINE BIOSYNTHETIC ENZYME PDX1 HOMOLOGUE, PUTATIVE Chains: A, B
Molecule details ›
Chains: A, B
Length: 297 amino acids
Theoretical weight: 32.73 KDa
Source organism: Plasmodium berghei
Expression system: Escherichia coli BL21(DE3)
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand PO4 4 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: R32
Unit cell:
a: 180.471Å b: 180.471Å c: 102.042Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.183 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Vitamin B₆ and Its Role in Cell Metabolism and Physiology.
Parra et al. (2018)
2 more

3 mentions without citation

Structural Dynamics and Perspectives of Vitamin B6 Biosynthesis Enzymes in Plasmodium: Advances and Open Questions.
Barra et al. (2021)
2 more