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Crystal structure of FolX from Pseudomonas aeruginosa

Source organism: Pseudomonas aeruginosa
Biochemical function: isomerase activity
Biological process: folic acid-containing compound metabolic process
Cellular component: cytosol

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EC 5.1.99.7: Dihydroneopterin triphosphate 2'-epimerase

Reaction catalysed:
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
Systematic name:
7,8-dihydroneopterin 3'-triphosphate 2'-epimerase
Alternative Name(s):
  • D-erythro-7,8-dihydroneopterin triphosphate epimerase
  • FolX (gene name)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02152
Domain description: Dihydroneopterin aldolase
Occurring in:
  1. Dihydroneopterin triphosphate 2'-epimerase
The deposited structure of PDB entry 4aey contains 1 copy of Pfam domain PF02152 (Dihydroneopterin aldolase) in Dihydroneopterin triphosphate 2'-epimerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006157
Domain description: Dihydroneopterin aldolase/epimerase domain
Occurring in:
  1. Dihydroneopterin triphosphate 2'-epimerase
IPR043133
Domain description: GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase
Occurring in:
  1. Dihydroneopterin triphosphate 2'-epimerase
IPR006156
Domain description: Dihydroneopterin aldolase
Occurring in:
  1. Dihydroneopterin triphosphate 2'-epimerase

Structure domain

CATH CATH domain
3.30.1130.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GTP Cyclohydrolase I, domain 2
Homology: GTP Cyclohydrolase I, domain 2
Occurring in:
  1. Dihydroneopterin triphosphate 2'-epimerase
The deposited structure of PDB entry 4aey contains 1 copy of CATH domain 3.30.1130.10 (GTP Cyclohydrolase I, domain 2) in Dihydroneopterin triphosphate 2'-epimerase. Showing 1 copy in chain A.

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