› 4ag4

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211955 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Epithelial discoidin domain-containing receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 351 amino acids
Theoretical weight: 39.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q08345 (Residues: 29-367; Coverage: 38%)
  • Best match: Q08345-4 (Residues: 29-189)
Gene names: CAK, DDR1, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Sequence domains:
Structure domains:
MONOCLONAL ANTIBODY 3E3 HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 23.03 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
MONOCLONAL ANTIBODY 3E3 LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.41 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 102.51Å b: 251.48Å c: 75.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.286
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.
Fu et al. (2013)
14 more

6 mentions without citation

Discoidin domain receptor functions in physiological and pathological conditions.
Leitinger B. (2014)
5 more