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Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.

<div class='caption-title'>3D structure of hANG and the comparison of hANG-ALS variant structures at the mutation sites.</div>
<div class='caption-title'>Uptake and localization of WT hANG and hANG-ALS variants in SY5Y cells.</div>
<div class='caption-title'>Effects of WT hANG and hANG-ALS variants on post-mitotic motor neuron (MN) number and morphology.</div>
Thiyagarajan N, Ferguson R, Subramanian V, Acharya KR
OpenAccess logo Nat Commun 3 1121 (2012)
Related entries: 4ahd, 4ahe, 4ahf, 4ahg, 4ahh, 4ahj, 4ahk, 4ahl, 4ahm, 4ahn, 4aoh

Cited: 55 times
EuropePMC logo PMID: 23047679

Abstract

Mutations in angiogenin (ANG), a member of the ribonuclease A superfamily, are associated with amyotrophic lateral sclerosis (ALS; sporadic and familial) and Parkinson's disease. We have previously shown that ANG is expressed in neurons during neuro-ectodermal differentiation, and that it has both neurotrophic and neuroprotective functions. Here we report the atomic resolution structure of native ANG and 11 ANG-ALS variants. We correlate the structural changes to the effects on neuronal survival and the ability to induce stress granules in neuronal cell lines. ANG-ALS variants that affect the structure of the catalytic site and either decrease or increase the RNase activity affect neuronal survival. Neuronal cell lines expressing the ANG-ALS variants also lack the ability to form stress granules. Our structure-function studies on these ANG-ALS variants are the first to provide insights into the cellular and molecular mechanisms underlying their role in ALS.

Articles - 4ahi mentioned but not cited (1)

  1. Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons. Thiyagarajan N, Ferguson R, Subramanian V, Acharya KR. Nat Commun 3 1121 (2012)


Reviews citing this publication (16)

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Articles citing this publication (38)

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