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Crystal structure of S. aureus FabI in complex with NADP and 5-ethyl- 2-phenoxyphenol

Source organism: Staphylococcus aureus
Biochemical function: enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Biological process: fatty acid biosynthetic process
Cellular component: not assigned

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EC 1.3.1.39: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)

Reaction catalysed:
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
Systematic name:
Acyl-[acyl-carrier protein]:NADP(+) oxidoreductase (Re-specific)
Alternative Name(s):
  • Acyl-ACP dehydrogenase
  • Acyl-[acyl-carrier-protein]:NADP(+) oxidoreductase (A-specific)
  • Acyl-[acyl-carrier-protein]:NADP(+) oxidoreductase (Re-specific)
  • Enoyl-ACp reductase
  • Enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase
  • Enoyl-[acyl-carrier-protein] reductase (NADPH(2), A-specific)
  • Enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)
  • FabL (gene name)
  • NADPH 2-enoyl Co A reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADPH]
The deposited structure of PDB entry 4alk contains 8 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in Enoyl-[acyl-carrier-protein] reductase [NADPH]. Showing 1 copy in chain F.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADPH]
IPR014358
Domain description: Enoyl-[acyl-carrier-protein] reductase (NADH)
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADPH]
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADPH]

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADPH]
The deposited structure of PDB entry 4alk contains 8 copies of CATH domain 3.40.50.720 (Rossmann fold) in Enoyl-[acyl-carrier-protein] reductase [NADPH]. Showing 1 copy in chain F.

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