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Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides.

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Masuyer G, Schwager SL, Sturrock ED, Isaac RE, Acharya KR
OpenAccess logo Sci Rep 2 717 (2012)
Cited: 79 times
EuropePMC logo PMID: 23056909

Abstract

Angiotensin-I converting enzyme (ACE), a two-domain dipeptidylcarboxypeptidase, is a key regulator of blood pressure as a result of its critical role in the renin-angiotensin-aldosterone and kallikrein-kinin systems. Hence it is an important drug target in the treatment of cardiovascular diseases. ACE is primarily known for its ability to cleave angiotensin I (Ang I) to the vasoactive octapeptide angiotensin II (Ang II), but is also able to cleave a number of other substrates including the vasodilator bradykinin and N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), a physiological modulator of hematopoiesis. For the first time we provide a detailed biochemical and structural basis for the domain selectivity of the natural peptide inhibitors of ACE, bradykinin potentiating peptide b and Ang II. Moreover, Ang II showed selective competitive inhibition of the carboxy-terminal domain of human somatic ACE providing evidence for a regulatory role in the human renin-angiotensin system (RAS).

Reviews - 4aph mentioned but not cited (4)

  1. Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective. Borkotoky S, Dey D, Hazarika Z. Mol Biol Rep 50 2713-2721 (2023)
  2. Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review. de Matos PH, da Silva TP, Mansano AB, Gancedo NC, Tonin FS, Pelloso FC, Petruco MV, de Melo EB, Fernandez-Llimos F, Sanches ACC, de Mello JCP, Chierrito D, de Medeiros Araújo DC. Inflamm Res 71 1489-1500 (2022)
  3. Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies. Toigo L, Dos Santos Teodoro EI, Guidi AC, Gancedo NC, Petruco MV, Melo EB, Tonin FS, Fernandez-Llimos F, Chierrito D, de Mello JCP, de Medeiros Araújo DC, Sanches ACC. Daru 31 51-68 (2023)
  4. Scrutinizing Coronaviruses Using Publicly Available Bioinformatic Tools: The Viral Structural Proteins as a Case Study. Beeckmans S, Van Driessche E. Front Mol Biosci 8 671923 (2021)

Articles - 4aph mentioned but not cited (20)

  1. Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides. Masuyer G, Schwager SL, Sturrock ED, Isaac RE, Acharya KR. Sci Rep 2 717 (2012)
  2. High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity. Lu J, Sun PD. J Biol Chem 295 18579-18588 (2020)
  3. Epigallocatechin gallate and theaflavin gallate interaction in SARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study. Maiti S, Banerjee A. Drug Dev Res 82 86-96 (2021)
  4. Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones. Wilson DJ, Shi C, Teitelbaum AM, Gulick AM, Aldrich CC. Biochemistry 52 926-937 (2013)
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  6. A heptameric peptide purified from Spirulina sp. gastrointestinal hydrolysate inhibits angiotensin I-converting enzyme- and angiotensin II-induced vascular dysfunction in human endothelial cells. Heo SY, Ko SC, Kim CS, Oh GW, Ryu B, Qian ZJ, Kim G, Park WS, Choi IW, Phan TT, Heo SJ, Kang DH, Yi M, Jung WK. Int J Mol Med 39 1072-1082 (2017)
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  13. In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity. Maiti S, Banerjee A, Kanwar M. Vascul Pharmacol 138 106856 (2021)
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  15. Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea. Lu Y, Wang Y, Huang D, Bian Z, Lu P, Fan D, Wang X. J Zhejiang Univ Sci B 22 575-589 (2021)
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  17. Computational evaluation of the reactivity and pharmaceutical potential of an organic amine: A DFT, molecular dynamics simulations and molecular docking approach. Abraham CS, Muthu S, Prasana JC, Armaković S, Armaković SJ, Rizwana B F, Geoffrey B, David R HA. Spectrochim Acta A Mol Biomol Spectrosc 222 117188 (2019)
  18. Molecular dynamic simulation suggests stronger interaction of Omicron-spike with ACE2 than wild but weaker than Delta SARS-CoV-2 can be blocked by engineered S1-RBD fraction. Santra D, Maiti S. Struct Chem 33 1755-1769 (2022)
  19. research-article High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity. Lu J, Sun PD. bioRxiv 2020.07.01.182659 (2020)
  20. Mechanistic Insights into Angiotensin I-Converting Enzyme Inhibitory Tripeptides to Decipher the Chemical Basis of Their Activity. Lammi C, Boschin G, Bartolomei M, Arnoldi A, Galaverna G, Dellafiora L. J Agric Food Chem 70 11572-11578 (2022)


Reviews citing this publication (12)

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  3. Unraveling the Pivotal Role of Bradykinin in ACE Inhibitor Activity. Taddei S, Bortolotto L. Am J Cardiovasc Drugs 16 309-321 (2016)
  4. Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence. Masuyer G, Yates CJ, Sturrock ED, Acharya KR. Biol Chem 395 1135-1149 (2014)
  5. How to design a potent, specific, and stable angiotensin-converting enzyme inhibitor. Regulska K, Stanisz B, Regulski M, Murias M. Drug Discov Today 19 1731-1743 (2014)
  6. Amaranth as a Source of Antihypertensive Peptides. Nardo AE, Suárez S, Quiroga AV, Añón MC. Front Plant Sci 11 578631 (2020)
  7. Reviewing Mechanistic Peptidomics in Body Fluids Focusing on Proteases. Magalhães B, Trindade F, Barros AS, Klein J, Amado F, Ferreira R, Vitorino R. Proteomics 18 e1800187 (2018)
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  8. Angiotensin Converting Enzyme Regulates Cell Proliferation and Migration. Alvarenga EC, Fonseca MC, Carvalho CC, Florentino RM, França A, Matias E, Guimarães PB, Batista C, Freire V, Carmona AK, Pesquero JB, de Paula AM, Foureaux G, Leite MF. PLoS One 11 e0165371 (2016)
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