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Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).

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Kolstoe SE, Jenvey MC, Purvis A, Light ME, Thompson D, Hughes P, Pepys MB, Wood SP
OpenAccess logo Acta Crystallogr D Biol Crystallogr 70 2232-40 (2014)
Related entries: 4avs, 4avt, 4ayu

Cited: 5 times
EuropePMC logo PMID: 25084341

Abstract

Under physiological conditions, the pentameric human plasma protein serum amyloid P component (SAP) binds hexanoyl bis(D-proline) (R-1-{6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl}pyrrolidine-2-carboxylic acid; CPHPC) through its D-proline head groups in a calcium-dependent interaction. Cooperative effects in binding lead to a substantial enhancement of affinity. Five molecules of the bivalent ligand cross-link and stabilize pairs of SAP molecules, forming a decameric complex that is rapidly cleared from the circulation by the liver. Here, it is reported that X-ray analysis of the SAP complex with CPHPC and cadmium ions provides higher resolution detail of the interaction than is observed with calcium ions. Conformational isomers of CPHPC observed in solution by HPLC and by X-ray analysis are compared with the protein-bound form. These are discussed in relation to the development of CPHPC to provide SAP depletion for the treatment of amyloidosis and other indications.

Articles - 4avv mentioned but not cited (1)

  1. Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC). Kolstoe SE, Jenvey MC, Purvis A, Light ME, Thompson D, Hughes P, Pepys MB, Wood SP. Acta Crystallogr D Biol Crystallogr 70 2232-2240 (2014)


Reviews citing this publication (1)

  1. Sialic acid as a target for the development of novel antiangiogenic strategies. Chiodelli P, Urbinati C, Paiardi G, Monti E, Rusnati M. Future Med Chem 10 2835-2854 (2018)

Articles citing this publication (3)

  1. Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase. Patrikainen MS, Tolvanen MEE, Aspatwar A, Barker HR, Ortutay C, Jänis J, Laitaoja M, Hytönen VP, Azizi L, Manandhar P, Jáger E, Vullo D, Kukkurainen S, Hilvo M, Supuran CT, Parkkila S. PeerJ 5 e4128 (2017)
  2. Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans. Klotz SA, Bradley N, Lipke PN. Pathogens 11 1000 (2022)
  3. Reaction Pathway Sampling and Free-Energy Analyses for Multimeric Protein Complex Disassembly by Employing Hybrid Configuration Bias Monte Carlo/Molecular Dynamics Simulation. Kurisaki I, Tanaka S. ACS Omega 6 4749-4758 (2021)


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