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The crystal structure of human Importin alpha 5 with TERT NLS peptide

Source organism: Homo sapiens
Biochemical function: nuclear import signal receptor activity
Biological process: protein import into nucleus
Cellular component: cytoplasm

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EC 2.7.7.49: RNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • DNA nucleotidyltransferase (RNA-directed)
  • RNA revertase
  • RNA-dependent DNA polymerase
  • RNA-dependent deoxyribonucleate nucleotidyltransferase
  • RNA-instructed DNA polymerase
  • RT
  • Reverse transcriptase
  • Revertase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00514
Domain description: Armadillo/beta-catenin-like repeat
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
The deposited structure of PDB entry 4b18 contains 8 copies of Pfam domain PF00514 (Armadillo/beta-catenin-like repeat) in Importin subunit alpha-5, N-terminally processed. Showing 8 copies in chain A.

PF16186
Domain description: Atypical Arm repeat
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
The deposited structure of PDB entry 4b18 contains 1 copy of Pfam domain PF16186 (Atypical Arm repeat ) in Importin subunit alpha-5, N-terminally processed. Showing 1 copy in chain A.

PF01749
Domain description: Importin beta binding domain
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
The deposited structure of PDB entry 4b18 contains 1 copy of Pfam domain PF01749 (Importin beta binding domain) in Importin subunit alpha-5, N-terminally processed. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000225
Domain description: Armadillo
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
IPR032413
Domain description: Atypical Arm repeat
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
IPR024931
Domain description: Importin subunit alpha
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed

Structure domain

CATH CATH domain
1.25.10.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Leucine-rich Repeat Variant
Homology: Leucine-rich Repeat Variant
Occurring in:
  1. Importin subunit alpha-5, N-terminally processed
The deposited structure of PDB entry 4b18 contains 1 copy of CATH domain 1.25.10.10 (Leucine-rich Repeat Variant) in Importin subunit alpha-5, N-terminally processed. Showing 1 copy in chain A.

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