Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + acceptor + H(2)O = a [histone H3]-N(6)-methyl-L-lysine(4) + formaldehyde + reduced acceptor
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129967 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lysine-specific histone demethylase 1A
Molecule details ›
Chain: A
Length: 686 amino acids
Theoretical weight: 76.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains:
Structure domains:
Length: 686 amino acids
Theoretical weight: 76.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
O60341 (Residues: 172-369, 370-852; Coverage: 80%) - Best match: O60341-2 (Residues: 192-876)
Sequence domains:
Structure domains:
REST corepressor 1
Molecule details ›
Chain: B
Length: 133 amino acids
Theoretical weight: 15.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains:
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Length: 133 amino acids
Theoretical weight: 15.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical: Q9UKL0 (Residues: 311-443; Coverage: 27%)
Sequence domains:
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1
