› 4bod

X-ray diffraction
3.15Å resolution

Complement regulator acquiring outer surface protein BbCRASP-4 or ErpC from Borrelia burgdorferi

Released:
DOI: 10.2210/pdb4bod/pdb
PDB entry 4bod coloured by chain, front view.
PDB entry 4bod coloured by chain, side view.
PDB entry 4bod coloured by chain, top view.
Source organism: Borreliella burgdorferi B31
Primary publication:
Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H.
Brangulis K, Petrovskis I, Kazaks A, Akopjana I, Tars K
Biochim Biophys Acta 1854 349-55 (2015)
PMID: 25582082

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ErpC Chains: A, B
Molecule details ›
Chains: A, B
Length: 157 amino acids
Theoretical weight: 17.49 KDa
Source organism: Borreliella burgdorferi B31
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q44790 (Residues: 27-179; Coverage: 86%)
Gene name: erpC
Sequence domains: Borrelia outer surface protein E
Structure domains: Borrelia outer surface protein E/F

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P41
Unit cell:
a: 71.16Å b: 71.16Å c: 75.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.142 0.139 0.196
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion.
Hovingh et al. (2016)
2 more

2 mentions without citation

Complement Evasion by Lyme Disease Spirochetes.
Skare et al. (2020)
1 more