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Structure of the Mycobacterium tuberculosis APS kinase CysC in complex with ADP and APS

Source organism: Mycobacterium tuberculosis
Biochemical function: ATP binding
Biological process: sulfate assimilation
Cellular component: not assigned

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EC 2.7.7.4: Sulfate adenylyltransferase

Reaction catalysed:
ATP + sulfate = diphosphate + adenylyl sulfate
Systematic name:
ATP:sulfate adenylyltransferase
Alternative Name(s):
  • ATP sulfurylase
  • ATP-sulfurylase
  • Adenosine-5'-triphosphate sulfurylase
  • Adenosinetriphosphate sulfurylase
  • Adenylylsulfate pyrophosphorylase
  • Sulfate adenylate transferase
  • Sulfurylase

EC 2.7.1.25: Adenylyl-sulfate kinase

Reaction catalysed:
ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate
Systematic name:
ATP:adenylyl-sulfate 3'-phosphotransferase
Alternative Name(s):
  • 5'-phosphoadenosine sulfate kinase
  • APS kinase
  • Adenosine 5'-phosphosulfate kinase
  • Adenosine phosphosulfate kinase
  • Adenosine phosphosulfokinase
  • Adenosine-5'-phosphosulfate-3'-phosphokinase
  • Adenylylsulfate kinase
  • Adenylylsulfate kinase (phosphorylating)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01583
Domain description: Adenylylsulphate kinase
Occurring in:
  1. Bifunctional enzyme CysN/CysC
The deposited structure of PDB entry 4bzq contains 2 copies of Pfam domain PF01583 (Adenylylsulphate kinase) in Bifunctional enzyme CysN/CysC. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002891
Domain description: Adenylyl-sulfate kinase
Occurring in:
  1. Bifunctional enzyme CysN/CysC
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Bifunctional enzyme CysN/CysC

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Bifunctional enzyme CysN/CysC
The deposited structure of PDB entry 4bzq contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Bifunctional enzyme CysN/CysC. Showing 1 copy in chain A.

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