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Crystal structure of 3-ketosteroid delta1-dehydrogenase from Rhodococcus erythropolis SQ1 in complex with 1,4-androstadiene-3,17- dione

Source organism: Rhodococcus erythropolis
Biochemical function: 3-oxosteroid 1-dehydrogenase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.3.99.4: 3-oxosteroid 1-dehydrogenase

Reaction catalysed:
A 3-oxosteroid + acceptor = a 3-oxo-Delta(1)-steroid + reduced acceptor
Systematic name:
3-oxosteroid:acceptor Delta(1)-oxidoreductase
Alternative Name(s):
  • 1-ene-dehydrogenase
  • 3-ketosteroid-1-en-dehydrogenase
  • 3-ketosteroid-Delta(1)-dehydrogenase
  • 3-oxosteroid Delta(1)-dehydrogenase
  • 3-oxosteroid:(2,6-dichlorphenolindophenol) Delta(1)-oxidoreductase
  • 3-oxosteroid:(acceptor) Delta(1)-oxidoreductase
  • 4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase
  • Delta(1)-dehydrogenase
  • Delta(1)-steroid reductase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00890
Domain description: FAD binding domain
Occurring in:
  1. FAD-dependent oxidoreductase 2 FAD binding domain-containing protein
The deposited structure of PDB entry 4c3y contains 8 copies of Pfam domain PF00890 (FAD binding domain) in FAD-dependent oxidoreductase 2 FAD binding domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. FAD-dependent oxidoreductase 2 FAD binding domain-containing protein
IPR027477
Domain description: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
Occurring in:
  1. FAD-dependent oxidoreductase 2 FAD binding domain-containing protein
IPR003953
Domain description: FAD-dependent oxidoreductase 2, FAD binding domain
Occurring in:
  1. FAD-dependent oxidoreductase 2 FAD binding domain-containing protein
IPR038052
Domain description: Chaperonin-like RbcX superfamily
Occurring in:
  1. FAD-dependent oxidoreductase 2 FAD binding domain-containing protein

Structure domains

CATH CATH domains
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. FAD-dependent oxidoreductase 2 FAD binding domain-containing protein
The deposited structure of PDB entry 4c3y contains 8 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in FAD-dependent oxidoreductase 2 FAD binding domain-containing protein. Showing 1 copy in chain A.
3.90.700.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Flavocytochrome C3; Chain A, domain 1
Homology: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Occurring in:
  1. FAD-dependent oxidoreductase 2 FAD binding domain-containing protein
The deposited structure of PDB entry 4c3y contains 8 copies of CATH domain 3.90.700.10 (Flavocytochrome C3; Chain A, domain 1) in FAD-dependent oxidoreductase 2 FAD binding domain-containing protein. Showing 1 copy in chain A.

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