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Human DPP1 in complex with (2S)-N-((1S)-1-cyano-2-(4-(4-cyanophenyl) phenyl)ethyl)piperidine-2-carboxamide

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.14.1: Dipeptidyl-peptidase I

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.
Systematic name:
-
Alternative Name(s):
  • Cathepsin C
  • Cathepsin J
  • DAP I
  • Dipeptide arylamidase I
  • Dipeptidyl aminopeptidase I
  • Dipeptidyl transferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Dipeptidyl peptidase 1 heavy chain
The deposited structure of PDB entry 4cdd contains 2 copies of Pfam domain PF00112 (Papain family cysteine protease) in Dipeptidyl peptidase 1 heavy chain. Showing 1 copy in chain B.

PF08773
Domain description: Cathepsin C exclusion domain
Occurring in:
  1. Dipeptidyl peptidase 1 exclusion domain chain
The deposited structure of PDB entry 4cdd contains 2 copies of Pfam domain PF08773 (Cathepsin C exclusion domain) in Dipeptidyl peptidase 1 exclusion domain chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Dipeptidyl peptidase 1 heavy chain
  2. Dipeptidyl peptidase 1 light chain
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Dipeptidyl peptidase 1 heavy chain
  2. Dipeptidyl peptidase 1 light chain
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Dipeptidyl peptidase 1 heavy chain
  2. Dipeptidyl peptidase 1 light chain
IPR036496
Domain description: Cathepsin C, exclusion domain superfamily
Occurring in:
  1. Dipeptidyl peptidase 1 exclusion domain chain
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Dipeptidyl peptidase 1 light chain
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Dipeptidyl peptidase 1 light chain
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Dipeptidyl peptidase 1 heavy chain
IPR014882
Domain description: Cathepsin C exclusion
Occurring in:
  1. Dipeptidyl peptidase 1 exclusion domain chain

Structure domains

CATH CATH domains
2.40.50.170
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Cysteine proteinases. Chain C
Occurring in:
  1. Dipeptidyl peptidase 1 light chain
The deposited structure of PDB entry 4cdd contains 2 copies of CATH domain 2.40.50.170 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Dipeptidyl peptidase 1 light chain. Showing 1 copy in chain C.
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Dipeptidyl peptidase 1 heavy chain
The deposited structure of PDB entry 4cdd contains 2 copies of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Dipeptidyl peptidase 1 heavy chain. Showing 1 copy in chain B.
2.40.128.80
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Lipocalin
Homology: Cathepsin C, exclusion domain
Occurring in:
  1. Dipeptidyl peptidase 1 exclusion domain chain
The deposited structure of PDB entry 4cdd contains 2 copies of CATH domain 2.40.128.80 (Lipocalin) in Dipeptidyl peptidase 1 exclusion domain chain. Showing 1 copy in chain A.

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